Endocrine Abstracts

Introduction: Copeptin is the C-terminal fragment of proAVP and provides an alternative measure of AVP secretion. While direct measurement of AVP during hypertonic saline infusion has been recommended as a diagnostic test for diabetes insipidus (DI), the number of reports examining the utility of copeptin in this context is limited. Here we describe a series of cases where measurement of copeptin during saline infusion has contributed to ...

Introduction: Pregnancy under the age of 19 is considered high-risk1; and a pregnancy with diabetes at this age further increases that risk2,3. With the correct advice and counselling, these risks can be greatly reduced. Here we describe a strategy to raise awareness by addressing this as part of regular clinic visits.Method: Prior knowledge of potential complications of pregnancy was assessed as part of a clinical consultation. Evi...

Post-prandial hypoglycaemia (PPH) can be associated with debilitating symptoms. Causes include altered physiology post-bariatric and upper gastrointestinal (GI) surgery and rarely noninsulinoma pancreatogenous hypoglycemia syndrome and insulin antibodies. We present a case of 49y female with no prior GI surgery presenting with debilitating hypoglycaemia with blood glucose falling to 2.8 mmol/l responding to glucose. Freestyle Libre monitoring confirmed hypoglycaemia 2-3 h post...

Background and Aim: Hepatic de novo lipogenesis (DNL) has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Supplementation with the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decreases intrahepatic triacylglycerol (IHTAG) and plasma TAG concentrations, which is suggested to be mediated through changes in hepatic DNL. We investigated the effects of omega-3 FA supplementation on intrahepatic DNL an...

Introduction: Hospital schools can provide structure and learning for young people throughout a planned admission. With guidance, teachers can be a vital resource for assessing the numeracy and literacy skills essential in the management of diabetes. They can also provide a source of valuable pastoral and organisational expertise useful to the diabetes multidisciplinary team (MDT).Method: School teaching, pastoral and planning skills can be used to help ...

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic disease. 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis. Steroid hormones, including glucocorticoids, as well as bile acids are established regulators of metabolic phenotype. We hypothesized that AKR1D1 plays a crucial regulatory role in hepatic metabolic homeostasis. Genetic manipulatio...

Non-alcoholic fatty liver disease is the hepatic manifestation of metabolic disease. 5β-reductase (AKR1D1) is highly expressed in human and rodent liver where it inactivates steroid hormones and catalyzes a fundamental step in bile acid synthesis. Steroid hormones, including glucocorticoids, as well as bile acids are established regulators of metabolic phenotype. We have hypothesized that AKR1D1 plays a crucial regulatory role in hepatic metabolic homeostasis.<p class...

Introduction: Medullary thyroid cancer arises from the calcitonin-secreting parafollicular C cells and consists of a spectrum of disease that ranges from extremely indolent tumours, where patients may survive for many years with a large tumor burden, to aggressive types associated with a high mortality rate. The objective of our study is to evaluate the prognostic factors and outcomes of patients diagnosed with medullary thyroid cancer in a homogenous population, and to examin...

Introduction: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterised by ACTH resistance and isolated glucocorticoid deficiency. Mutations of ACTH receptor, known as melanocortin-2 receptor (MC2R), and melanocortin-2 receptor accessory protein (MRAP) account for approximately 25 and 15 to 20% of cases respectively. To date there is no strong evidence that heterozygous carriers have abnormal cortisol secretion.Case: We...

Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, ...